Rapamycin CD8⁺ T cells have enhanced ability to survive <i>in vivo</i>.

<p>P14 CD44^loCD8⁺ T_N were stimulated for 6 days <i>in vitro</i> with B6-derived DCs pulsed with gp33 plus IL-2, in the absence or presence of rapamycin (100 nM). T cells were collected 6 days after culture, washed and injected via tail vein into normal Thy1.1 B6 mice. One day later, donor cells were recovered from the spleen, LN and PB for measuring the number of infused donor T cells. Dot plots show the fraction of donor T cells. All data are shown as means ± SD and representative of two independently performed experiments with 3 mice in each group. *<i>p</i><0.05, significant difference.