Binding affinities for selected pharmacophore hit compounds at the α₁-adrenoceptors (ARs).

<p><i>n</i> represents the number of experiments, each performed in triplicate.</p><p>Ø represents no binding at concentrations up to 100 µM.</p>a<p>p<i>K</i>_i (−Log <i>K</i>_i).</p>b<p><i>K</i>_i (inhibition constants) are the antilog of mean p<i>K</i>_i.</p><p><i>K</i>_i values were calculated according to the equation of Cheng and Prusoff . <i>K</i>_i = IC₅₀/1 + ([L]/<i>K</i>_D) when [L] is the radioligand concentration and <i>K_D</i> its dissociation constant.</p>A<p>indicates significant differences from the α_1A –AR (<i>p</i><0.05).</p>B<p>indicates significant differences from the α_1B –AR (<i>p</i><0.05).</p>D<p>indicates significant differences from the α_1D –AR (<i>p</i><0.05).