METH down regulates glucose uptake in human neurons:

<p><b>A.</b> Dose dependent effects of METH on D-(2-³H)-glucose uptake by human neurons for 24 hr. <b>B.</b> Effects of GLUT inhibitor cytochalasin B (10 µM) and ALC (100 µM) on glucose uptake by neurons following 20 µM and 100 µM of METH for 24 hr. <b>C.</b> Effect of 20 µM METH on D-(2-³H)-glucose uptake in human neurons at 24, 48 and 72 hr exposure periods and compared with respective untreated control cells. Statistically significant, *p<0.05, **p<0.01 compared with controls (n = 5 in <b>A</b> and <b>B</b>, n = 3 in <b>C</b>); ^##p<0.01 with 100 µM of METH (in <b>B</b>, n = 5).