<p>(a) epinephrine; (b) pindolol; (c) salbutamol; and (d) salmeterol. The spare receptors were normalized in percentage.</p
<p>(<b>A</b>) An initial signal (black) elicits a response in the fraction of bound receptors (RL, p...
<p>(A) Change in phosphoThr34 DARPP-32 is similar to that observed experimentally in response to 10 ...
G protein coupled receptor agonists can be described by two parameters; affinity (ability to bind a ...
<p>(a) The effect of an EC<sub>100</sub> of each agonist (calculated where the total receptor is unc...
A mathematical model is presented that simulates the steady tency of an agonist is dependent upon th...
In the presence of agonists, many neurotransmitter receptors interact with regulatory components, re...
Accurate ranking of efficacies and potencies of agonists is essential in the discovery of new select...
We have investigated the utility of curves used to represent concentration (or dose) plotted against...
The aim of this work is practical. We show that the parameters of the widely used operational model ...
<p>Receptor concentrations (<i>c<sub>r</sub></i>) simulated with the stochastic model and the corres...
Many receptor-level processes involve the diffusion and reaction of receptors with other membrane-lo...
Abstract Agonist efficacy denoting the “strength” of agonist action is a cornerstone in the proper a...
We describe a modification of receptor theory for the estima-tion of observed affinities (Kobs) and ...
We describe a modification of receptor theory for the estima-tion of observed affinities (Kobs) and ...
When an agonist activates a population of G protein-coupled receptors (GPCRs), it elicits a signalin...
<p>(<b>A</b>) An initial signal (black) elicits a response in the fraction of bound receptors (RL, p...
<p>(A) Change in phosphoThr34 DARPP-32 is similar to that observed experimentally in response to 10 ...
G protein coupled receptor agonists can be described by two parameters; affinity (ability to bind a ...
<p>(a) The effect of an EC<sub>100</sub> of each agonist (calculated where the total receptor is unc...
A mathematical model is presented that simulates the steady tency of an agonist is dependent upon th...
In the presence of agonists, many neurotransmitter receptors interact with regulatory components, re...
Accurate ranking of efficacies and potencies of agonists is essential in the discovery of new select...
We have investigated the utility of curves used to represent concentration (or dose) plotted against...
The aim of this work is practical. We show that the parameters of the widely used operational model ...
<p>Receptor concentrations (<i>c<sub>r</sub></i>) simulated with the stochastic model and the corres...
Many receptor-level processes involve the diffusion and reaction of receptors with other membrane-lo...
Abstract Agonist efficacy denoting the “strength” of agonist action is a cornerstone in the proper a...
We describe a modification of receptor theory for the estima-tion of observed affinities (Kobs) and ...
We describe a modification of receptor theory for the estima-tion of observed affinities (Kobs) and ...
When an agonist activates a population of G protein-coupled receptors (GPCRs), it elicits a signalin...
<p>(<b>A</b>) An initial signal (black) elicits a response in the fraction of bound receptors (RL, p...
<p>(A) Change in phosphoThr34 DARPP-32 is similar to that observed experimentally in response to 10 ...
G protein coupled receptor agonists can be described by two parameters; affinity (ability to bind a ...
DOI
Add to ORKG