Enhanced <i>I_NaP</i> in A-type neurons of the compressed DRG.

<p>(A) Traces of <i>I_NaP</i> in A-type neurons from control (normal; grey line) and compressed (CCD, solid line) DRGs (bottom) as induced by increasing applied voltage (top). (B) Bar graph showing that the average peak <i>I_NaP</i> is significantly greater in neurons recorded from compressed DRGs (CCD; n = 31) compared to the average peak value from control group recordings (normal; n = 26; *P<0.05). (C) Bar graph showing that average peak <i>I_NaP</i> current density is significantly greater in compressed DRG neurons (n = 31) compared to the average peak value from control group recordings (n = 26; *P<0.05). (D) Steady state activation curves for <i>I_NaP</i> conductance with respect to voltage in control and compressed DRG neurons as fit with a Boltzmann distribution equation. The differences are not statistically significant. (E) Traces of <i>I_NaP</i> in a compressed DRG neuron in the absence (control, solid line) and presence (DMSO, grey line) of 0.1% DMSO (bottom) as induced by increasing applied voltage (top). (F) Bar graph showing that average peak <i>I_NaP</i> in compressed DRG neurons (n = 7) in the presence of 0.1% DMSO is not significantly different from the average peak <i>I_NaP</i> in the absence of DMSO (control, filled; n = 7; P>0.05).