<p>(<b>A</b>) A representative SA-ß-gal staining of young and senescent HUVECs. (<b>B</b>) Immunoblotting analysis of S6-S235/S236 (p-S6), total S6, and tubulin protein levels in the young and senescent endothelial cells. Quantification of the signals is shown in the lower panel. n = 6 in each group. **p<0.01. Scale bar = 0.2 mm.</p
Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senesc...
Senescent cells exhibit several typical features, including the senescence-associated secretory phen...
<p>(A) mRNA levels of ITSN2, EPS15, HSP70, and JAK2 were compared in young and old fibroblasts. Leve...
<p>Young HUVECs were transduced either with an empty rAd vector as control or with rAd/CMV-HA-S6K1-c...
<p>Senescent HUVECs were transduced either with rAd/U6-LacZ<sup>shRNA</sup> as control or with rAd/U...
<p>Young or senescent HUVECs were treated with either solvent or resveratrol (Resv, 10 µmol/L) for o...
Ageing is the major risk factor for the development of cardiovascular diseases. Endothelial cells pl...
<p>(<b>A</b>) Immunoblotting analysis of eNOS-dimers and -monomers in the young and senescent HUVEC ...
Research on vascular endothelial cell ageing helps elucidate the pathogenesis of diseases associated...
<p>(<b>A</b>) Young HUVEC cells were transduced either with an empty rAd vector as control or with r...
<p>Fluorescent signals of (<b>A</b>) MitoSox, (<b>B</b>) DHE, and (<b>C</b>) DAF-2DA staining for de...
Small extracellular vesicles (EVs) are novel players in vascular biology. However, a thorough unders...
Endothelial senescence is characteristic of vascular aging. Serum- and glucocorticoid-inducible kina...
Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads...
<p><b>A.</b> Representative images showing morphological changes associated with senescence in c-Myc...
Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senesc...
Senescent cells exhibit several typical features, including the senescence-associated secretory phen...
<p>(A) mRNA levels of ITSN2, EPS15, HSP70, and JAK2 were compared in young and old fibroblasts. Leve...
<p>Young HUVECs were transduced either with an empty rAd vector as control or with rAd/CMV-HA-S6K1-c...
<p>Senescent HUVECs were transduced either with rAd/U6-LacZ<sup>shRNA</sup> as control or with rAd/U...
<p>Young or senescent HUVECs were treated with either solvent or resveratrol (Resv, 10 µmol/L) for o...
Ageing is the major risk factor for the development of cardiovascular diseases. Endothelial cells pl...
<p>(<b>A</b>) Immunoblotting analysis of eNOS-dimers and -monomers in the young and senescent HUVEC ...
Research on vascular endothelial cell ageing helps elucidate the pathogenesis of diseases associated...
<p>(<b>A</b>) Young HUVEC cells were transduced either with an empty rAd vector as control or with r...
<p>Fluorescent signals of (<b>A</b>) MitoSox, (<b>B</b>) DHE, and (<b>C</b>) DAF-2DA staining for de...
Small extracellular vesicles (EVs) are novel players in vascular biology. However, a thorough unders...
Endothelial senescence is characteristic of vascular aging. Serum- and glucocorticoid-inducible kina...
Accumulation of senescent endothelial cells can cause endothelium dysfunction which eventually leads...
<p><b>A.</b> Representative images showing morphological changes associated with senescence in c-Myc...
Cellular senescence irreversibly arrests cell proliferation, accompanied by a multi-component senesc...
Senescent cells exhibit several typical features, including the senescence-associated secretory phen...
<p>(A) mRNA levels of ITSN2, EPS15, HSP70, and JAK2 were compared in young and old fibroblasts. Leve...