Resveratrol reduces superoxide generation and enhances NO production in senescent endothelial cells.

<p>Young and senescent HUVEC cells were treated with solvent as control (C), resveratrol (Resv, 10 µmol/L) or rapamycin (Rapa, 20 ng/ml) for one hour and then subjected to (<b>A</b>) MitoSox, (<b>B</b>) DHE, and (<b>C</b>) DAF-2DA staining. Quantification of the signals from six independent experiments is shown in the corresponding right panels. *p<0.05, **p<0.01 and ***p<0.001 between indicated groups. Scale bar = 0.2 mm.