GP42-H1 protects mice from lethal challenge with PR/8 virus.

<p>Mice that were administered AF, infected with 1LD₅₀ of PR/8 virus or immunized with 1,000 pfu of GP42-GFP, or 1,000 pfu GP42-H1 (i.n.) were challenged (seven weeks post-immunization) with 5LD₅₀ of PR/8 virus (i.n.) A) Body weight was recorded over 14 days and the percent of the body weight at the time of challenge is shown. B) Animals were monitored for 14 days post challenge and morbidity is recorded. Depicted are the percentages of mice that survived the virus challenge.