IgG response of individual Balb/c mice against Aβ (1–42) as determined by ELISA.

<p>As indicated on the x-axis, groups of eight mice were immunized with cyclo[Aβ (22–28)-YNGK′]-TTd, oligomeric Aβ(1–42), or fibrillar Aβ (1–42). <b>A</b>, coating antigen: oligomeric Aβ (1–42); <b>B</b>, coating antigen: fibrillar Aβ (1–42). A mouse with a serum titer ≤100 is considered to be a non-responder. The two titers out of range in the right panel of <b>A</b> have values of 40<b>×</b>10³ and 50<b>×</b>10³. The figure demonstrates that anti- cyclo[Aβ (22–28)-YNGK′] antibodies recognize oligomeric and fibrillar Aβ (1–42).