Representative images of corneal sections showing efficacy of AAV5-mediated transgene delivery in fibrotic rabbit corneas.

<p>Corneal fibrosis was produced by PRK laser surgery which induces transdifferentiation of keratocytes (myofibroblasts showing red staining for αSMA). Keratocytes expressing delivered GFP are shown in green (arrow), transdifferentiation keratocytes (myofibroblasts) expressing GFP and α-smooth muscle actin are shown in yellow (arrowheads), and transdifferentiation keratocytes (myofibroblasts) expressing α-smooth muscle actin are shown in red (Cut arrowheads). Nuclei are stained blue with DAPI. Scale bar denotes 100 µm.