Changes in Na⁺ channel associated parameters post-oxaliplatin in motor axons.

<p>A) Refractoriness pre (black bars) and post (white bars) single oxaliplatin infusion demonstrating significant change post-oxaliplatin in motor axons (Refractoriness Pre: 31.7±6.4%; Post 68.8±14.5%; <i>P</i>≤.001). B) Strength-duration time constant pre (black bars) and post (white bars) oxaliplatin infusion, demonstrating unchanged results following oxaliplatin treatment (Pre: 0.395±0.01 ms; Post: 0.394±0.02 ms; NS). C) Inset diagram of the changes in the recovery cycle of excitability pre- (black circles) and post-oxaliplatin infusion (white circles) for all patients, with error bars representing standard error of the mean and refractoriness outlined by a box and an arrow demonstrating direction of change.