Changes in Na⁺ channel associated parameters post-oxaliplatin in sensory axons.

<p>A) Refractoriness pre (black bars) and post (white bars) oxaliplatin treatment (Pre: 31.4±5.4%; Post: 21.4±5.5%; <i>P</i><.05), demonstrating significant reduction post-oxaliplatin in sensory axons. B) Strength-duration time constant pre (black bars) and post (white bars) treatment (Pre: 0.544±.03 ms; Post: 0.535±.05 ms; NS), with no significant effect post oxaliplatin treatment. C) Changes in the recovery cycle of excitability pre- (black circles) and post-oxaliplatin infusion (white circles) for all patients, with error bars representing standard error of the mean and refractoriness outlined by a box and an arrow demonstrating direction of change.