B7-H1 and PD-1 expression are highly upregulated on CD4⁺ and CD8⁺ CNS T cells from TMEV-infected SJL/J mice.

<p>CNS T cells from wild-type SJL/J mice at day 7 post-TMEV infection were analyzed for expression of B7-H1 and PD-1 molecules by flow cytometry. <b>A</b>. Histograms of B7-H1 and PD-1 expression on CD4⁺ and CD8⁺ T cells. Black shaded area represents isotype control and the grey line represents positive staining. A representative histogram from one individual mouse from three separate experiments is shown. <b>B</b>. Data is also represented as Δ mean fluorescence intensity (ΔMFI) of B7-H1 and PD-1 expression on CD4⁺ and CD8⁺ T cells. Expression of B7-H1 and PD-1 is significant greater (*p<0.05) on with CD8⁺ as compared to CD4⁺ T cells. Data are expressed as the average ± SEM.