Post-prandial lipid handling in hpa-Tg and C57BL/6 mice.

<p>(A) Absorption of radio-labeled vitamin A (³H-retinol). Intestinal absorption was 12% of the total administered dose of ³H-retinol in both hpa-Tg (n = 4) and C57BL/6 mice (n = 4). (B) Distribution of absorbed vitamin A (³H-retinol) in blood, liver and carcass. 41% of the radioactive retinol were detected in serum of hpa-Tg mice compared to 9% detected in serum of C57BL/6 mice, p<0.0001. No difference was detected in radioactivity extracted from carcasses of the two experimental groups. The decrease in liver uptake of retinol was paralleled by an equivalent increase in the level of labeled retinol in the blood of hpa-Tg mice.