Reduced rod function in <i>Guca1a</i>^COD3 ‘knock-in’ mice.

<p>(<b>a</b>) Representative ERG traces taken from dark-adapted 5 month-old wild-type, <i>Guca1a</i>^+/COD3 and <i>Guca1a</i>^COD3/COD3 mice, showing a reduction in a- and b-wave amplitude in mutant mice in the rod-dominated ERG in response to a series of increasing stimulus intensities. (<b>b</b>) Representative ERG traces taken from dark-adapted 12 month-old wild-type, <i>Guca1a</i>^+/COD3 and <i>Guca1a</i>^COD3/COD3 mice, showing that rod function is relatively spared when compared with cone function. (<b>c</b>) Averaged scotopic, rod-dominated b-wave amplitudes from wild-type, <i>Guca1a</i>^+/COD3 and <i>Guca1a</i>^COD3/COD3 mice recorded over a twelve month period from birth. Mean values were calculated from b-wave amplitudes from 100 mcds/m² flash intensity, which corresponds to a rod-only response. Note the age-related decline in wild-type mice. (<b>d</b>) Rod b-wave amplitudes in <i>Guca1a</i>^+/COD3 and <i>Guca1a</i>^COD3/COD3 mice plotted as a percentage of wild-type amplitudes over a twelve month period from birth.