Influence of LPA5 silencing on functional responses in LAD2 cells.

<p>(A) Calcium flux in response to the indicated concentrations of LPA in control (grey tracing) or shRNA treated cells (black tracing). (B) Maximum calcium flux in response to 1 µM LPA represented in bar graph form (N = 3 Mean ± SD, *P<0.05). (C) MIP-1β release six hours after exposure to 1 µM LPA from cells transduced with control vector or LPA5 shRNA (N = 3 Mean ± SD, *P<0.05). Determinations performed in three independent experiments.