Spectral karyotyping reveals pervasive aneuploidy in <i>Lmna^Dhe/+</i> fibroblasts.

<p>(A) Histogram of chromosome numbers in <i>Lmna^Dhe/+</i> (red bars) and <i>Lmna^+/+</i> (blue bars) dermal fibroblasts, as determined by metaphase spreading and SKY. Over 90% of mutant cells possessed an abnormal number of chromosomes ranging from 38 to 104. (B and C) Representative spectral karyotypes of <i>Lmna^+/+</i> (B) and <i>Lmna^Dhe/+</i> (C) cells. The wild-type cell exhibited a normal karyotype of 40XY (B), while the mutant cell was aneuploid with a 104XXXXX karyotype (C).