Calorie restriction and baseline home cage behavior of leptin knockout mice.

<p>(A) Leptin KO and WT mice on AL feeding conditions gain weight while Leptin KO and WT mice on CR lose weight. (B) Leptin KO mice on AL and CR feeding conditions have similar percent gain and loss of weight relative to percent changes in weight of WT controls on AL and CR feeding conditions. Leptin KO mice on CR are more resistant to weight loss (p<0.01 for Leptin KO CR vs. WT CR). (C) High activity behaviors of WT mice are much higher than Leptin KO mice. WT and Leptin KO mice have comparable (D) food bin entry on AL feeding. WT mice (E) hang, (F) jump, (G) rear and (H) walk more than Leptin KO mice. Statistics were performed using the Mann-Whitney Test * = p<0.05; ** = p<0.01; *** = p<0.001. Error bars represent IQR for behavioral data and SEM for body weight data. n = 16 WT AL and n = 15 KO AL.