Model for the assembly of RVFV.

<p>The diagram represents a slice through the middle of three hexameric capsomers of the virion. Hexameric capsomers contain six copies of heterodimeric Gn (dark gray) and Gc (light gray). Gn is predicted to have two transmembrane domains (TMD). N (green) binds within the first 30 amino acids of cytosolic tail and RdRp (red) binds within the latter 40 amino acids. The genomic segments (black), presumably the terminal regions, bind to the cytosolic tail of Gn. We hypothesize that Gn-N interactions across multiple capsomers induce a membrane curvature that leads to budding of the virion.