15d-PGJ₂ downregulated cortical neurons and BSMC.

<p>(A) Cortical neurons and BSMC were treated with vehicle (control) or 10 µM 15d-PGJ₂. Vehicle was 0.1% ethanol. Cell densities (open columns) and MTT-reducing activities (closed columns) in cortical neurons and BSMC were determined 24 h or 48 h later, respectively. (B) Cortical neurons and BSMC were treated with vehicle (control), PGD₂, PGJ₂, Δ¹²-PGJ₂ or 15d-PGJ₂ at 10 µM. Vehicle was 0.1% ethanol. MTT-reducing activities in cortical neurons (open columns) and BSMC (closed columns) were determined 8 h or 48 h later, respectively. Data are expressed as means ± S.E.M. (n = 4). **P<0.01, compared with control by ANOVA followed by Dunnett's test.