Clathrin-mediated endocytosis.

<p>(A) A schematic bird's-eye view of a mammalian cell showing randomly scattered clathrin-coated structures (green) positioned on the adherent cell surface. (B) Confocal immunofluorescence image of the adherent surface of HeLa cells stained with an antibody against the AP-2 adaptor protein showing coexistence of diffraction-limited spots (arrowheads) and large clathrin patches (arrows). (C) High-resolution electron micrograph of the adherent surface of a cultured fibroblast (courtesy of John Heuser) showing areas of flat clathrin lattice (pseudocolored in green). (D) Schematic depiction of the process of clathrin-coated vesicle assembly at the various types of bud site analyzed by Taylor et al. <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1001037#pbio.1001037-Taylor1" target="_blank">[33]</a>.