Altered functional signature in patients with active tuberculosis.

<p>Typical examples of cytokine profiles of PPD reactive CD4 T cells in patients with (<b>A</b>) successfully treated tuberculosis and (<b>C</b>) patients with active tuberculosis. Stimulated CD4 T cells were stratified into cells expressing IFN-γ only (upper left quadrant), IL-2 only (lower right quadrant), and dual-cytokine producing cells (upper right quadrant). The numbers in the three quadrants refer to the relative percentage of each cell population. These percentages are displayed for all patients with successfully treated tuberculosis (<b>B</b>) and active tuberculosis (<b>D</b>). The stippled line indicates the 56% threshold established by ROC analysis.