Development of spontaneous EAE in TCR transgenic mice.

<p>(<b>A</b>) RAG1 deficient mice were monitored for twelve months for overt signs of EAE (hind leg paraparesis). The day of the onset of EAE in individual mice is indicated on the chart. (<b>B</b>) More than 60% of MBPαβ mice and nearly all OVαβ TCR mice remained healthy throughout the course of the study, whereas 100% of the TCR transgenic RAG1 deficient became sick. Onset of disease was at an average of eleven weeks of age in all three susceptible mice.