Effect of mAb 1A8 and mAb RB6-8C5 treatment of mice prior to and during infection with BJx109, HKx31 or PR8.

<p>Groups of 5 B6 mice were treated with purified (A) anti-Ly6G (1A8) or (B) anti-Gr-1 (RB6-8C5) antibodies 24 hrs prior to virus infection and every second day thereafter. Control mice received rat IgG (IgG). Data show weight loss for mice infected with 10⁵ PFU of (i) BJx109, (ii) HKx31 or (iii) PR8. Mice were weighed daily and results expressed as the mean percent weight change of each group (± SEM), compared to original body weight. Animals that had lost ≥25% of their original body weight and/or presented with evidence of pneumonia were euthanized. Data shown are from one experiment and are representative of two independent experiments. The dashed line indicates days on which the weight loss induced by treatment with (A) mAb 1A8 or (B) mAb RB6-8C5 was statistically different to IgG-treated controls (<i>p</i><0.05, Student's <i>t</i>-test).