Relative change of resistance prevalence and inappropriately treated patients compared to mixing for ISS₇ (green points) and ISS_Last (black points).

<p>The figure shows the change conferred by ISS₇ and ISS_Last for an asymmetric scenario in which p_A0 = 0.1*2/3, p_0B = 0.1*1/3, c_A0 = 0.2 *1/3 and c_0B = 0.2*1/3 (i.e. the less costly mutant is more abundant). The x-axis corresponds to the mixing frequency M (see <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1001094#pcbi-1001094-t003" target="_blank">Table 3</a>). Note that the mixing and ISS₇ depend on M, whereas ISS_Last is independent of M. Points correspond to the mean over 10⁴ simulations, error-bars correspond to the 95% confidence interval of the mean, inferred through 1000 bootstrap samples.