<p>MTD: dose maximal tolerated dose;</p><p>*: p<0.05.</p><p>The total of trials within the same treatment categories could differ in the different lines because no data concerning MTD was available in 28 trials and because the first sign of efficacy was not linked to a dose-level in 64 trials.</p
<p>Likely effective, drugs to which isolate susceptible in laboratory testing. <i>n</i>, number of p...
Phase II clinical trials of experimental treatments play an essential role in drug development. Hist...
For almost half a century, systemic therapy of cancer has been dominated by the use of cytotoxic che...
Phase 1 trials play a crucial role in oncology by translating laboratory science into efficient ther...
PURPOSE: Phase 1 trials play a crucial role in oncology by translating laboratory science into effic...
Phase I trials use a small number of patients to define a maximum tolerated dose (MTD) and the safet...
INTRODUCTION: Because a dose-response relationship is characteristic of conventional chemotherapy, t...
Introduction: Because a dose-response relationship is characteristic of conventional chemotherapy, t...
Introduction: Because a dose–response relationship is characteristic of conventional chemotherapy, t...
<p>The red pins indicate DLT and the size of the pins correspond to the time to DLT since patients a...
<p>Likely effective, drugs to which isolate susceptible in laboratory testing. <i>n</i>, number of p...
Background: A widely used phase I design in clinical trials of chemotherapy for cancer and for AIDS ...
The primary goal of phase I dose-finding trials has been historically to understand the safety profi...
In Phase I oncology trials, the main objective is typically to determine the maximum tolerated dose ...
AIMS: There is a trend for more flexibility in timing of evidence generation in relation to marketin...
<p>Likely effective, drugs to which isolate susceptible in laboratory testing. <i>n</i>, number of p...
Phase II clinical trials of experimental treatments play an essential role in drug development. Hist...
For almost half a century, systemic therapy of cancer has been dominated by the use of cytotoxic che...
Phase 1 trials play a crucial role in oncology by translating laboratory science into efficient ther...
PURPOSE: Phase 1 trials play a crucial role in oncology by translating laboratory science into effic...
Phase I trials use a small number of patients to define a maximum tolerated dose (MTD) and the safet...
INTRODUCTION: Because a dose-response relationship is characteristic of conventional chemotherapy, t...
Introduction: Because a dose-response relationship is characteristic of conventional chemotherapy, t...
Introduction: Because a dose–response relationship is characteristic of conventional chemotherapy, t...
<p>The red pins indicate DLT and the size of the pins correspond to the time to DLT since patients a...
<p>Likely effective, drugs to which isolate susceptible in laboratory testing. <i>n</i>, number of p...
Background: A widely used phase I design in clinical trials of chemotherapy for cancer and for AIDS ...
The primary goal of phase I dose-finding trials has been historically to understand the safety profi...
In Phase I oncology trials, the main objective is typically to determine the maximum tolerated dose ...
AIMS: There is a trend for more flexibility in timing of evidence generation in relation to marketin...
<p>Likely effective, drugs to which isolate susceptible in laboratory testing. <i>n</i>, number of p...
Phase II clinical trials of experimental treatments play an essential role in drug development. Hist...
For almost half a century, systemic therapy of cancer has been dominated by the use of cytotoxic che...
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