<p>Shown is a schematic diagram depicting the multiple targets of ZAS3 involved in the regulation of RANK signaling, important for osteoclastogenic differentiation and function. Binding of RANKL to RANK activates cytoplasmic ZAS3 that (i) induces expression of TRAF6 and association of ZAS3 and TRAF6 leading to the recruitment of TGF-β-activated kinase 1 (TAK1) binding protein 2/3 (TAB2/3) to polyubiquitinated TRAF6, which in turn activates TAB1/TAK1, inhibitor of NF-kB alpha (IkBα) kinase (IKK) complexes, and nuclear translocation of NF-kB p50/p65; (ii) Simultaneously, ZAS3 activates mitogen-activated protein kinases to activate the transcription factor AP-1 via phosphorylation of p38 and assembly of c-Jun/Fos; (iii) ZAS3 associates with c-...
Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and regulat...
<p>(A) Morphological changes and increase in TRAP expression of RAW264.7 cells upon sRANKL-mediated ...
Bone plays a pivotal role in storing calcium and phosphate in vertebrates. This tissue is maintained...
Mice deficient in the large zinc finger protein, ZAS3, show postnatal increase in bone mass suggesti...
Mice deficient in the large zinc finger protein, ZAS3, show postnatal increase in bone mass suggesti...
<p>RAW264.7 cells (from 500 to 2500 cells) were stably transfected with the empty vector (EV) or the...
<p>(A) Western blot analysis of total protein lysates prepared from bone marrow macrophages (BMM) cu...
<p>Upon receptor engagement, in addition to transduce apoptosis signaling pathway, TRAIL induces act...
Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusi...
Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone...
Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone...
<p>(A) Genes with H3K4me3 peaks within +/- 1 kb from TSS were defined as K4(+) genes, and genes with...
AbstractReceptor activator of NF-κB (RANK) is a recently cloned member of the tumor necrosis factor ...
Based on our earlier observation that caspase-3 is present in osteoclasts that are not undergoing ap...
This review focuses on the signal transduction of cytokine receptors and of osteoclastogenesis. C...
Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and regulat...
<p>(A) Morphological changes and increase in TRAP expression of RAW264.7 cells upon sRANKL-mediated ...
Bone plays a pivotal role in storing calcium and phosphate in vertebrates. This tissue is maintained...
Mice deficient in the large zinc finger protein, ZAS3, show postnatal increase in bone mass suggesti...
Mice deficient in the large zinc finger protein, ZAS3, show postnatal increase in bone mass suggesti...
<p>RAW264.7 cells (from 500 to 2500 cells) were stably transfected with the empty vector (EV) or the...
<p>(A) Western blot analysis of total protein lysates prepared from bone marrow macrophages (BMM) cu...
<p>Upon receptor engagement, in addition to transduce apoptosis signaling pathway, TRAIL induces act...
Osteoclasts are multinucleated cells formed mainly on bone surfaces in response to cytokines by fusi...
Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone...
Maintenance of healthy bone requires the balanced activities of osteoclasts (OCs), which resorb bone...
<p>(A) Genes with H3K4me3 peaks within +/- 1 kb from TSS were defined as K4(+) genes, and genes with...
AbstractReceptor activator of NF-κB (RANK) is a recently cloned member of the tumor necrosis factor ...
Based on our earlier observation that caspase-3 is present in osteoclasts that are not undergoing ap...
This review focuses on the signal transduction of cytokine receptors and of osteoclastogenesis. C...
Osteoclasts require coordinated co-stimulation by several signaling pathways to initiate and regulat...
<p>(A) Morphological changes and increase in TRAP expression of RAW264.7 cells upon sRANKL-mediated ...
Bone plays a pivotal role in storing calcium and phosphate in vertebrates. This tissue is maintained...