Relative changes in the content of amino acid in blood during the course of infection in <i>T. b. b.</i>-infected rats.

<p>The changes in the concentration of amino acids (mean value ± SEM) in the blood of infected rats were normalized with the corresponding values obtained in healthy control animals. 100% of the control values (delineated by the dotted line) correspond to: 110±3 µM for L-arginine; 100±4 µM for L-citrulline; 95±4 µM for L-glutamate and 0.96±0.1 µM for ADMA. Statistics: ANOVA followed by post-hoc Fisher's test (<i>*p<0.05</i>, <i>**p<0.001</i>, <i>***p<0.0001</i> compared to healthy rats); n = 6 animals in each group at the different times post-infection: D5, D10, D16 and D22. Abbreviations: ADMA, asymmetric dimethylarginine; see also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016891#pone-0016891-g002" target="_blank">figure 2</a>.