Increased CD16⁺ monocytes in peripheral blood and liver positively correlate with liver injury in IA patients.

<p>(A) The major CD16⁺ monocytes and CD14^highCD16⁺ monocyte subsets were significantly correlelated with serum ALT levels, but not with HBV DNA. The solid line represents the linear growth trend and <i>r</i>, the correlative coefficient. <i>P</i> values are shown. (B) Representative dot plots of CD14 and CD16 staining in monocytes from peripheral blood and LILs isolated from the the same IA patient are shown. Values in the upper-left and upper-right quadrants represent the percentages of CD14^highCD16⁻ monocytes and CD16⁺ monocytes, respectively. (C) Individual percentages of hepatic and peripheral monocytes that express CD16 from the IA patients. Each dot represents one individual. <i>P</i> values are shown. (D) IA patients with higher HAI scores (G and S) have a higher percentage of monocytes expressing CD16 in their livers, compared to patients with lower HAI scores. <i>P</i> values are shown. ALT, alanine aminotransferase; HAI, histological activity index; LILs, intrahepatic leukocytes.