MT4-MMP null mice have increased urine osmolarity compared to control mice.

<p>(<b>A</b>) Urine osmolarity obtained at baseline (0) and following 24 hr water deprivation (24) reveals that MT4-MMP null mice have higher baseline urine osmolarity (*p = 0.0164) vs C57/BL6 time point 0. Both groups of animals appropriately concentrate their urines following water deprivation. (<b>B</b>) Plasma osmolarity, (<b>C</b>) Plasma sodium and (<b>D</b>) Blood urea nitrogen were the same in both groups.