Time course of skin wound healing in <i>Mmp13;Plau</i> and <i>Mmp13;Plg</i> double-deficient mice.

<p>(<b>A</b>+<b>C</b>) The percentage fraction of mice with complete re-epithelialization is plotted vs. time after incision of 20 mm long wounds. (<b>B</b>+<b>D</b>) The average wound length is plotted vs. time after incision. Wound healing in <i>Mmp13</i>-deficient mice is indistinguishable from that in wild-type mice, while wound healing in both <i>Plau</i>- and <i>Plg</i>-deficient mice is significantly delayed compared to wildtype wound healing (p = 0.002 and p<0.001 in a two-tailed <i>t</i>-test). However, <i>Mmp13;Plau</i> and <i>Mmp13;Plg</i> double-deficient mice have an additional significant delay in wound healing compared to either <i>Plau</i>- or <i>Plg</i>-deficient mice (p = 0.016 and p<0.001 in a two-tailed t-test), indicating a phenotypic overlap between MMP-13 and the PA system.