<i>RSPO1</i> expression increases at key stages of early human ovary development.
- Sara Tomaselli (139009)
- Francesca Megiorni (199949)
- Lin Lin (46073)
- Maria Cristina Mazzilli (229178)
- Dianne Gerrelli (356819)
- Silvia Majore (356822)
- Paola Grammatico (356823)
- John C. Achermann (110416)
Publication date
February 2013
DOIAbstract
<p>(A) Analysis of <i>CTNNB1</i>, <i>WNT4</i>, and <i>RSPO1</i> in human fetal gonads between 6–9 weeks post-conception. Testis and ovary samples showed higher expression of <i>CTNNB1</i> (ANOVA, p<0.001), <i>WNT</i>4 (ANOVA, p<0.01) and <i>RSPO1</i> (ANOVA, p<0.001) compared to control. Significantly higher expression of <i>RSPO1</i> was detected in the ovary compared to testis (**p<0.01). (B) Analysis of <i>RSPO1</i> expression levels in the testis and ovary during this period of development. A significant increase in <i>RSPO1</i> was found in the ovary across this time course (ANOVA, P<0.0001; 8w >6–7w and 9w >6–7w, both ***p<0.001) (control, 8 wpc heart).</p