Example pictures and results for the two different electrode sizes.

<p><b>A</b>. Tissue reaction to a 200 µm un-tethered implant after twelve weeks. Sections are immunohistochemically labelled for GFAP (red), ED1 (green) and DAPI (blue). Scale bar lower right is 100 µm. The orientation of the picture is indicated as rostral (R) caudal (C) medial (M) and lateral (L). <b>B</b>. Tissue reaction to a 50 µm un-tethered implant after twelve weeks. Sections are immunohistochemically labelled for GFAP (red), ED1 (green) and DAPI (blue). Scale bar lower right is 100 µm. ***p<0.001. <b>C</b>. Quantified GFAP density surrounding (0–200 µm) the implants with respect to diameter. The columns indicate the mean and bars show the standard error of the mean. ***p<0.001. <b>D</b>. Quantified ED1 density surrounding (0–200 µm) the implants with respect to diameter. The columns indicate the mean and bars show the standard error of the mean. ***p<0.001. <b>E</b>. Number of neurons surrounding (0–200 µm) the implants with respect to diameter. The columns indicate the mean and bars show the standard error of the mean. ***p<0.001.