GABA_AR Mediated Tonic Inhibition in MGB Neurons:

<p><b>A</b>) Representative traces of gaboxadol-induced tonic Cl⁻ currents (outward) revealed by gabazine block, resulting in an inward shift in baseline current for MGB neurons held at −10 mV. The solid black line above the first trace represents the continuous focal application of (50 µM) gabazine for all traces. <b>B</b>) Bar graph of tonic current amplitude changes revealed by focal application of gabazine in the presence of increasing concentrations of GABA_AR agonist, gaboxadol (GBX), applied to the ACSF. Current amplitudes are represented on the y-axis with the concentration of gaboxadol on the x-axis. (*<i>p</i><0.005 when compared to Control using Dunnett's post-hoc analysis, data underwent first-order Winsorization; n = control: 8; 0.1 µM: 4; 0.3 µM: 6; 1 µM: 6; 2 µM: 6; 5 µM: 6).