<i>Pik3c3</i> deleted blastocysts show defects in cell proliferation in culture.

<p><b>A.</b> Representative images of cultured blastocysts from a heterozygous control embryo. Embryos were collected from heterozygous intercrosses at E3.5 and genotyped after cultured <i>in vitro</i> for 8 days. Inner cell mass (ICM) and trophoblast giant cells (TGC) are indicated at Day 8. <b>B.</b> Representative images of cultured blastocysts from a homozygous mutant embryo. Mutant embryos have defects in proliferation.