Grooming gross and its change responses to immobilization stress in different genotypes.

<p>(A) Number of bouts and (B) Total time of durations of grooming. Box plot graphs represent the distribution of values of the behavioral responses. Boxes extend from the 25th to 75th percentiles and were divided by a solid line representing the median of each group. Whiskers extend from the 5th to 95th percentiles. Each outlier was denoted by a dot. *, <i>p</i><0.05; **, <i>p</i><0.01; ***, <i>p</i><0.001, one way ANOVA. (C) and (D), the changes of grooming bouts and durations in different genotypes. The asterisks (*, <i>p</i><0.05; **, <i>p</i><0.01; ***, <i>p</i><0.001, One way ANOVA) indicate in each genotype, the significant differences in the behavioral responses of the stressed mice compared to the non-stressed mice which is designated as 1. # indicate the significant differences of change-fold in behavioral responses between genotypes (#, <i>p</i><0.05; ##, <i>p</i><0.01; ###, <i>p</i><0.001, one way ANOVA). M-WT, wild-type mice on the mixed back-ground; Per1 M, <i>Per1</i> mutant mice; Per2 M, <i>Per2</i> mutant mice.