Long-term protection against heterologous lethal challenge by M2 VLP vaccination.
- Jae-Min Song (329011)
- Bao-Zhong Wang (329013)
- Kyoung-Mi Park (329009)
- Nico Van Rooijen (40828)
- Fu-Shi Quan (329010)
- Min-Chul Kim (329007)
- Hyun-Tak Jin (357487)
- Andrew Pekosz (357488)
- Richard W. Compans (111751)
- Sang-Moo Kang (329015)
Publication date
February 2013
DOIAbstract
<p>(A–B) At six months after prime-boost immunizations with M2 VLPs, mice (n = 5) were challenged with a lethal dose (3× LD<sub>50</sub>) of A/PR/8/34 (H1N1) influenza virus. A) Body weight changes, B) Survival rates. (C–D) Mice (n = 5) that were intranasally immunized with M2 VLPs 7 months earlier were challenged with A/Philippines/82 (H3N2) virus. Body weight changes (C) and survival rates (D) are shown.</p
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