Immobilization stress induced change of grooming and nociceptive behaviors in M-WT and C57/B6 mice.

<p>Box plot graphs in A represent the distribution of values of the behavioral responses in non-stressed state. See legend to <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0016212#pone-0016212-g001" target="_blank">figure 1</a> for details. (A1) Number of grooming bouts. (A2) Total time of grooming durations. (A3) Withdrawal response to mechanical stimuli. (A4) Withdrawal latency to thermal stimuli. In basal grooming and nociceptive behavioral values, there were no significant differences between these two strains. Histograms in B represent the changes of grooming gross and nociceptive response after immobilization stress in M-WT and C57/B6 mice. (B1) Grooming bouts. (B2) Duration of grooming. (B3) Mechanical sensitivity. (B4) Thermal sensitivity. The asterisks (*, <i>p</i><0.05; **, <i>p</i><0.01; ***, <i>p</i><0.001, One way ANOVA) indicate in M-WT and C57/B6 mice, the significant differences in the behavioral responses of stressed mice compared to the non-stressed mice, which is designated as 1. In change-fold of all behavioral responses, there were no significant differences between these two strains.