Treatment with Gr1+ depleting antibody results in significant decrease in lung neutrophils.

<p>B6 mice were infected with ∼100 CFU <i>M.tuberculosis</i> via the aerosol route and treated with either isotype control antibody (Isotype) or Gr1 depleting antibody between days 10–15 (D10–D15) post infection. Cells were isolated from antibody treated <i>M.tuberculosis</i>-infected mice and the percentage of lung neutrophils were determined on day 15 (a) or day 21(b) by flow cytometry. The data points represent the mean (±SD) of values from five mice (a–b) _***, <i>p</i>≤0.0005 over isotype control treated <i>M.tuberculosis</i>-infected samples.