Comparison between colorectal and leukaemic cell lines.

<p>For comparative purposes the effects of digitoxin on DNA and protein synthesis (A and B respectively) were also monitored in the colorectal adenocarcinoma cell line Hct116. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015718#pone-0015718-g004" target="_blank">Figure 4C</a> shows differences in cytotoxic activity of digitoxin in the Hct116 cell line and the leukaemic cell lines (CCRF-CEM and SUP-B15) used in the present study. In <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015718#pone-0015718-g004" target="_blank">Figure 4D</a> the effects on survival (at 72 h, measured by FMCA) and protein synthesis at 24 hours at digitoxin concentrations slightly exceeding the IC₅₀ values in HT29 and SUP-B15 cells are shown.