Pathology in the brain of <i>dcr</i> mice.

<p>A) A coronal section of a <i>dcr</i> mouse indicates bilaterally symmetric loss of neurons in the lateral, inferior cerebral cortex (arrowheads). B) The tissue loss is consistent with a regional ischemia resulting in complete vacuolization of the tissue in the affected region with normal surrounding tissue. C) Other regions of the brain such as the dorsal medial cortex eventually become affected. D) Dilated blood vessels are often present in the brains of affected mice. E) Activated astrocytes in the striatum stained for GFAP indicate stress reactions in regions of the brain that do not show obvious pathology (Arrowheads). Note that E is from additional sectioning of the same sample in a region comparable to D.