Phenotype of mutants for housekeeping genes are similar and depend on p53 network upregulation.

<p><b>A–C</b>) Excessive neural apoptosis was manifested as gray areas in the brain at 24 hpf, which was rescued by p53 inhibition <b>D–F</b>) At 48 hpf, there were more apoptotic cells in mutants compared to siblings and p53 inhibition led to a decrease in apoptosis. Acridine orange staining. <b>G–I</b>) There were fewer erythroid cells in mutants compared to siblings, which was rescued by p53 inhibition. o-dianizidine staining, 84 hpf, arrow points to erythrocytes. <b>K–L</b>) <i>tp53</i> upregulation was higher in the brain and blood cells, 48 hpf, in situ hybridization, arrow points to erythrocytes.