<i>tp53</i> and its targets were upregulated in all studied mutants.

<p><b>A</b>) The level of <i>tp53</i> upregulation varied between mutants. <b>B</b>) Δ<i>113tp53</i> is a p53 target and p53 inhibitor, a part of p53 autoregulatory loop. <b>C–D</b>) Cell cycle suppressor <i>cdkn1a (p21</i>) and <i>cyclin G1</i> were upregulated. <b>E–F</b>) Pro-apoptotic <i>puma</i> and <i>bax</i> were upregulated in mutants. 48 hpf, qPCR.