LVSCE/AMVAD vaccine reduces the bacterial burdens in the lungs and spleen.

<p>Five mice per naïve, and LVSCE, LVSCE/AMVAD or LVSCE/CT immunized groups challenged with 3.4×10⁴ cfu of <i>F. tularensis</i> LVS in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015574#pone-0015574-g004" target="_blank">Figure 4</a> experiment were euthanized at 1 or 4 d post-challenge, and the <i>F. tularenisis</i> burden (log₁₀ cfu/organ) in the lungs (A) and spleen (B) determined. The data are presented as mean log₁₀ cfu ± SD for each group, at each time point (n = 5). The dotted line represents the detection limit. ^*<i>p</i><0.05 and ^**<i>p</i><0.01 vs. LVSCE alone immunized group. Data are representative of two separate experiments.