Common pathways to cancer and neurodegeneration?

<p>An illustration of some of the genes that are linked to cancer and neurodegeneration, and the crosstalk plus overlap between them. Although the links between genes involved in the individual disorders themselves are not yet completely clear (for example, there is evidence that there may be several parallel pathways leading to cell loss in the <i>substantia nigra</i> and the clinical symptom of parkinsonism), there is an intriguing picture emerging of fundamental links between cell proliferation and cell death. ALP, autophagy-lysosome pathway; UPS: ubiquitin-proteasome system.