Zinc accumulation in neuritic plaques in APP/PS1 mice.

<p>(<b>A</b>) Zinc ions stained by AMG showing the distribution patterns of zinc ions in the cortex and hippocampus, especially mossy fibers. Importantly, the number and size of the zinc-containing plaques were increased in Zn-treated mice. (<b>B</b>) Statistical analysis showing that the number and size of zinc-containing neuritic plaques were significantly increased in Zn-treated mice compared with controls. ** <i>p</i><0.01 versus control group (Student's <i>t</i> test).