The effect of RAL and HAFi <i>in vivo</i>.

<p><b>A.</b> The effect of RAL and HAFi <i>in vivo</i> on mouse skin. Histological sections of vehicle- (a), RAL- (b), HAFi- (c) or RAL- and HAFi- (d) treated DBA/1 and vehicle (e) or RAL- (f) treated CD44-/- mouse dorsal skin. Note the significant epidermal hyperplasia in DBA/1 but not in CD44-/- mice. <b>B.</b> Epidermal thickness in SKH1, DBA/1 and CD44-/- mouse dorsal skin measured with an ocular micrometer. Ten measurements were performed per mouse and the average value was calculated. The results are presented as the mean epidermal thickness ± SEM of six animals per group. ***p<0.001 versus vehicle (student's t test). <b>C.</b> Ki67 staining of vehicle- (a), RAL- (b), HAFi- (c) or RAL- and HAFi- (d) treated DBA/1 and vehicle (e) or RAL- (f) treated CD44-/- mouse dorsal skin.