Severe hyperinsulinemia and insulin resistance in <i>Leptin^145E/145E</i> mice.

<p>(<b>A</b>) Serum glucose and insulin levels during 5-hr fasting of <i>Leptin^145E/145E</i> and <i>Leptin^+/+</i> mice. (<b>B</b>) Serum glucose and insulin levels during glucose tolerance tests in 3-month-old male littermates (n = 5∼9). Impaired insulin sensitivity revealed by (<b>C</b>) IR index and (<b>D</b>) insulin tolerance tests of 3-month-old female <i>Leptin^145E/145E</i> mice (n = 8) compared to <i>Leptin^+/+</i> mice (n = 10). (<b>E</b>) Fasting serum triglyceride (TG, left panel), cholesterol (Chol, middle panel), and free fatty acid (FFA, right panel). (<b>F</b>) Serum levels of adiponectin (left panel) and leptin (right panel) of <i>Leptin^145E/145E</i> and <i>Leptin^+/+</i> mice. Numbers of mice are inside bars. *<i>P</i><0.05, **<i>P</i><0.01, and ***<i>P</i><0.001 against <i>Leptin^+/+</i>.