Nurr1 +/− mice exhibit greater reduction of striatal TH-immunoreactivity following METH exposure.

<p>(A) METH injection reduced THir in +/+ and +/− mice following one time binge METH exposure (1X METH) and repeated binge METH exposure (2XMETH). Calibration = 2 mm. (B) Quantitative THir fiber density analysis indicated that binge METH treatment significantly reduces THir in striatum and 2XMETH induced a further reduction of the THir in both +/+ and +/− mice. There is a significant difference between saline and 1XMETH group (p<0.001, Two-way ANOVA) and between 1XMETH and 2XMETH group (p<0.001, Two-way ANOVA) in striatal THir. In addition, there is also a significant difference (p<0.001) between +/+ and +/− mice after 1XMETH injection.