Nurr1 +/− mice exhibit decreased TH-immunoreactivity in SNpr following methamphetamine exposure.

<p>(A) TH immunostaining indicates that METH administration augments the reduction in THir in the SNpr of Nurr1 +/−, compared to +/+ mice following repeated METH binge treatment. Calibration bar = 500 um. (B) THir fiber density analysis indicated METH treatment (1xMETH) reduced THir fiber density in SNpr in +/+ and +/− mice (p<0.001, Two-way ANOVA) and repeated METH binge treatment (2XMETH) further reduced THir fiber density in SNpr (p<0.001, Two-way ANOVA). A trend of greater reduction in TH immunoreactivity was found in the Nurr1 +/− mice following 1XMETH (p = 0.058, Two-way ANOVA, post hoc Newman-Keuls test) and a significant decrease in THir in SNpr was found in Nurr1 +/− mice following repeated METH treatment (2XMETH). (p<0.05, Two-way ANOVA, post hoc Newman-Keuls test).